DNA sensors can be detected when the COVID is contagious

Friday, September 24, 2021 (HealthDay News)

New DNA sensor can detect virus And tell in minutes if they are infectious, new studies will find.

The sensor is developed using DNA technology and does not require pretreatment of test samples.Researchers have demonstrated this technology in humans Adenovirus (I caught a cold, influenza) And the causative virus COVID-19 (New Coronavirus Infection)..

“The state of infectivity is that the patient Infectious Or if the environmental disinfection method works. ” Researcher Anapeinetti, who conducted the study as a postdoctoral fellow at the University of Illinois at Urbana-Champaign (UIUC), said.

“We have developed these highly specific DNA molecules called aptamers. This is more than just recognition. virus It is also possible to distinguish the infection status of the virus. ” In a university news release, she now leads a research group at the University of Buenos Aires, Argentina.

Researcher YiLu, an emeritus professor of chemistry at UIUC, explained that current measurements of viral RNA may not be an accurate indicator of infectivity.

“With the virus that causes it COVID-19 (New Coronavirus Infection), Viral RNA levels have been shown to have minimal correlation with viral infectivity.In the early stages of human infection, viral RNA is low and difficult to detect, but humans are very high. Infectious“He said in the release.

“If a person recovers and is not infectious, the RNA levels of the virus can be very high. Antigen testing [commonly used for COVID] It is slower than viral RNA, but follows a similar pattern. Therefore, both RNA and antigen tests for the virus are inadequate to tell if the virus is infectious. It can lead to delays in treatment and quarantine, or early release of people who may still be contagious. “

With the new sensor method, results can be obtained in 30 minutes to 2 hours. It does not require sample processing and can be used for viruses that do not propagate in the lab.

“We chose humans Adenovirus To demonstrate the sensor as it is a new water-borne viral pathogen of concern in the United States and around the world. “

“The ability to detect infectious adenovirus in the presence of viruses that have been made non-infectious by water disinfectants and other potentially interfering background substances in wastewater and contaminated natural water is unprecedented new. We provide an approach. We believe that such technologies may provide stronger protection for the environment, and public health. “

Researchers said the detection technology could be applied to other viruses by fine-tuning the DNA to target a variety of pathogens.

Researchers with the ability to distinguish between non-infectious and infectious viruses hope that the sensor will help them understand the mechanism of infection.

The report was published in the journal on September 22nd. Science Advances..

For more information

NS National Human Genome Institute There are more information about the virus.

Source: University of Illinois at Urbana-Champaign, News Release, September 22, 2021

Stephen Reinberg

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DNA sensors can be detected when the COVID is contagious

Source link DNA sensors can be detected when the COVID is contagious

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