Chagas vaccine shows promise in mice

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Friday, May 8, 2015 (HealthDay News)-Experimental vaccine Provides long-term protection for mice Chagas diseaseCan lead to death from heart And people’s bowel complications, researchers report.

Chagas disease It is widespread in most countries of Latin America and is an emerging infectious disease in the United States.Parasite called Cruise Trypanosoma Causes infection.

Not here vaccine Or the treatment of Chagas disease transmitted by the triatomin bug, often referred to as the “kiss bug”.

Researchers in the medical department at the University of Texas at Galveston Cruise Trypanosoma We have identified three proteins that have shown strong potential for genome and vaccine development.

“When the body initiates an immune response that produces antibodies, proteins become antigens,” said Shibari Gupta, a postdoctoral fellow in microbiology and immunology, in a university news release.

“We found that mice were vaccinated with these antigens shortly before infection. Cruise Trypanosoma It lowered the level of parasites and stopped the signs of Chagas disease in unvaccinated mice, “Gupta added.

Mice became infected with the parasite 4-6 months after vaccination. Some of them also received booster shots.

However, animal-based studies often do not give similar results in humans, so it is unclear whether the results will be reproduced in humans.

This study was published in the journal on May 7th. PLoS pathogen..

Eleven to 18 million people worldwide are infected with Chagas disease, and about 50,000 die from Chagas disease each year. According to a news release, 19 cases of Chagas disease were reported in Texas in 2013, most of them in the Houston area.

–Robert Preidt

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Source: University of Texas Galveston Medical College, News Release, May 7, 2015

Chagas vaccine shows promise in mice

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