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Baby acetaminophen associated with asthma

46% increase in risk asthma With baby Acetaminophen use

NS
Daniel J. Denoon
WebMD Health News

Reviewed by
Louise Chan, MD

September 18, 2008- Baby Who gets AcetaminophenTylenol Is one brand-higher risk as a kid asthma..

Acetaminophen, often given for treatment heat Increased risk again in the first year of life eczema Have I have a runny nose When itch eye.

This finding, from an international survey of 205,487 children in 31 countries, does not prove the cause of acetaminophen. asthma, eczema, Or nose /Eye problems..

However, it raises important safety concerns about the most commonly used drugs in the United States: heat-Reduces the painkiller acetaminophen (also known as paracetamol), which is the main component of Tylenol.

People should think twice about the use of acetaminophen, but no one should stop taking it or giving it to overpriced children heat, Says research leader Richard Beasley, DSc, a professor at the New Zealand Institute of Medicine.

“”[Acetaminophen] Use may be a risk factor for development
asthma As a child. This issue urgently requires randomized controlled trials, “Beeley told WebMD in an email interview.
[acetaminophen] Remains a preferred drug for salvation painWhen heat For use in childhood, and for both children and adults with asthma. “

Beasley says that parents give acetaminophen to their children heat More than 101 degrees Fahrenheit.

Studies show:

  • Children who took acetaminophen for fever in the first year of life had a 46% increased risk of asthma between the ages of 6 and 7.
  • Increased risk of runny nose and red by 48% itch Eyes of 6-7 years of age in children who took acetaminophen for fever in the first year of life.
  • 35% increased risk eczema Children 6-7 years old who took acetaminophen for fever in the first year of life.
  • People aged 6 to 7 years who take acetaminophen at least once a month are three times more at risk of current asthma symptoms than those who do not take the drug.
  • 22% of severe Childhood asthma It is associated with the use of acetaminophen in the first year of life.
  • 38% of severe childhood asthma is associated with the use of acetaminophen in late childhood.

Does acetaminophen cause asthma?

The Beasley study, which requires parents to remember the use of acetaminophen after the fact, cannot prove that acetaminophen causes asthma.

However, Beasley et al. State that there are several reasons to suspect this is the case.

  • The link between acetaminophen and asthma is strong.
  • The more acetaminophen your child uses, the higher the risk of severe asthma.
  • Acetaminophen is associated with asthma in many different cultures with different medical practices.
  • The use of acetaminophen has come before Asthma symptoms Appeared.
  • In the same year, the prevalence of asthma soared and the use of acetaminophen became widespread.

In an editorial accompanying the study, Columbia University researchers R. Graham Barr, MD, and DrPH said the study did not prove that acetaminophen causes asthma, but that clinical studies are urgently needed. I agree with

“This is a major public health concern,” Barr told WebMD. “Given the widespread use of acetaminophen, Ibuprofen Among children-and asthma is the most burdensome illness for children-this will seem to be an important topic for further research. “

Barr states that previous studies have linked acetaminophen, but not.
IbuprofenLinking the use of acetaminophen to asthma pregnancy For childhood asthma.

Barr’s own research team previously discovered that the use of high levels of acetaminophen increases women’s risk. Adult-onset asthma..

“There is still a lot of uncertainty about this,” he says. “Something may be happening, but are there any clear public health recommendations at this time? We don’t think so.”

Childhood lung problems increase adult asthma

A study from the University of Arizona, Tucson, emphasizes the importance of early childhood events to late asthma.

Fernando D. Martinez, MD, MD, director of the University of Arizona’s Arizona Breathing Center, and colleagues tracked 849 children from birth to the age of 22.

Patients with adult asthma include:

  • 7.4 times more likely to have childhood asthma
  • 14 times more likely to have persisted Wheezing As a child
  • 3.6 times more likely as a child Mold allergy
  • Double the chance that it was low Airway Function at 6 years old

Over 70% of adults with adult asthma were women.

“We conclude that asthma, which clearly develops in early adulthood, primarily affects women and is a clinical manifestation of potential changes in airway responses that are commonly present in preschool years.” They conclude.

A study by Beasley and Martinez, and an editorial by Barr, appeared in the September 20th issue of. Lancet..

Source: Beasley, R. Lancet, September 20, 2008; vol 372: pp1039-1048. Stern, DA Lancet, September 20, 2008; vol 372: pp1058-1064. Bar, RG Lancet, September 20, 2008; vol 372: pp1011-1012. WebMD Health News: “Before birth Acetaminophen: Asthma Link? “WebMD Health News:” Popular Painkiller It is associated with asthma. Richard Beasley, DSc, Professor of New Zealand Medical Research Institute, Wellington. R. Dr. Graham Barr, Associate Professor of Medicine and Epidemiology, DrPH, Columbia University, New York.

© 2008 WebMD, LLC. all rights reserved.



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