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All anger, but is it really safe and effective?

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Dennis Thompson
Health Day Reporter

Monday, May 7, 2018 (HealthDay News)-Cannabidiol (CBD) oil has become a popular new product in legalized states Medical marijuana..

Don’t get drunk Marijuana The extract is believed to have helped treat all medical problems from epilepsy Seizures To anxiety For inflammation insomnia..

But experts say there is little evidence for most of these advertised benefits.

To make matters worse, CBD is produced unregulated and the quality of the products varies greatly, says Marcel Bonn-Miller, a part-time assistant professor of psychiatry at the University of Pennsylvania School of Medicine.

“It’s really a wild west,” said Von Miller. “Joe Bob, who started the CBD company, was able to say whatever he wanted to say on the label and sell it to people.”

Cannabidiol is extracted from flowers and buds Marijuana Or hemp plants. It does not cause addiction. The “high” marijuana is caused by the chemical tetrahydrocannabinol (THC).

CBD oil is legal in 30 states where medicinal and / or recreational marijuana is legal. Governance magazine.

According to, 17 additional states have CBD-specific legislation in books Prevention magazine. They are Alabama, Georgia, Indiana, Iowa, Kentucky, Mississippi, Missouri, North Carolina, Oklahoma, South Carolina, South Dakota, Tennessee, Texas, Utah, Virginia, Wisconsin, Wyoming.

Strong evidence for treatment Epilepsy

The only purpose of use of cannabidiol for treatment Epilepsy, There is important scientific evidence to support it.

Last month, the U.S. Food and Drug Administration Advisory Board unanimously recommended approval of the CBD drug Epidiolex to treat two rare forms of childhood. Epilepsy..

Timothy Welty, director of clinical science at Drake University’s Faculty of Pharmaceutical Sciences and Health Sciences, said: In Des Moines, Iowa.

There is too little evidence to draw a firm conclusion on the remaining potential uses of CBD.

For example, some humans Clinical trial Suggests that CBD may be effective in treating symptoms of anxiety, Especially social anxietySaid Von Miller.

This is a potential use of CBD, EpilepsyBut “there is a decent gap between the two,” he said.

“was there Clinical trial In adults, but much smaller than Epilepsy A study conducted on children. “

The usefulness of CBD as an anti-inflammatory drug is next promising, but experts said their results were primarily obtained from animal studies.

Most other uses are rarely proven

Remaining Potential Uses-As Antipsychotics Antidepressant Or sleep Assistance “is all studied in animals, and there are only one or two examples of studies in humans,” said Von Miller.

And Welty said that studies involving humans for the use of these other CBDs were either case reports or studies that did not compare results with controls that did not use oil.

“Because there is no control, it’s basically a way to know if we’re dealing with the true effect of the drug, or just the placebo effect. I think someone has been given a beneficial drug. Because, “Welty said.

Experts added that there are also concerns about both the quality of the CBD oil produced and its potential side effects.

Lack of regulation

Due to the legally ambiguous nature of marijuana, the FDA has not intervened to regulate products like CBD oil, Von Miller said. The state is struggling to enforce regulations, but there is no deep federal pocket.

Meanwhile, a 2017 study led by Bonn-Miller found that nearly seven of the ten CBD products did not contain the amount of marijuana extract promised on the label.

According to Von Miller, nearly 43% of products contain too little CBD and about 26% contain too much.

“CBD is a kind of tricky drug because it isn’t well absorbed orally,” Welty explained. “Less than 20 percent of the drug is absorbed orally. If it isn’t made the right way, you may not have many drugs in your systemic circulation.”

To make matters worse, Bonn-Miller and his colleagues found that about one-fifth of CBD products contained intoxicating pot chemical THC.

“This is a problem because THC can increase. anxiety..It can actually be made Seizures Even worse. These are the types you need to be aware of, “said Von Miller.



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“If I was a consumer and bought for myself or my kids, I couldn’t trust what was on the label, so I’d like to test to see what’s actually in it.” Bonn-Miller concludes.

Potential interactions with other drugs

Studies on CBD also raised concerns about possible interactions with others. Drug..

For example Epilepsy Studies show that “blood levels of some other antiepileptic drugs have risen very clearly. Drug When people were using CBD, “Welty said.

This may mean that people taking antiepileptic drugs with CBD may need to lower their doses to avoid side effects, Welty said.

There are also some signs that CBD can be harmful liver..About 10% of people taking CBD in the study Liver enzymeShows the possibility liver Damage, Welty said.

“About 2-3 percent of individuals taking CBD actually had to stop for their reasons. Liver enzyme Very high and attracted people’s attention running Research. “

Welty recommends that anyone interested in CBD look for a doctor who has read about the extract and its potential uses.

“My final advice is that people really need to take care of healthcare providers who understand CBD. They need to be monitored and controlled by that individual. That’s the answer. It’s not just about buying CBD because you think it’s going to happen, “Welty said.

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References

Source: Marcel Bonn-Miller, Ph.D. , University of Pennsylvania School of Medicine, Philadelphia, Part-time Associate Professor of Psychiatry. Timothy Welty, Ph.D., Chairman of the Department of Clinical Sciences, Faculty of Pharmaceutical Sciences and Faculty of Health Sciences, Drake University, Des Moines, Iowa.



All anger, but is it really safe and effective?

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