Why Some People Avoid Type 1 Diabetes Complications

Researchers say more than just blood sugar Controls may be working in some patients

Along Kathleen Doheny
WebMD Health News

Was reviewed by Laura J. Martin, MD

March 29, 2011-After living together for years Diabetes mellitus, May cause complications, including problems that affect the eyes, heart, Kidneys, nerves.

However, some Type 1 diabetes “Veterans” seem to escape many or most of these Diabetic complications, According to a new study.

“This study clearly shows and documents that there may be many people who can go with us for a very long time. Type 1 diabetes You won’t suffer from dire complications, “said Joslyn’s chief scientific officer, Dr. George L. King, MD. Diabetes mellitus Harvard Medical School Center and Professor of Medicine.

The study is published at Diabetes mellitus Care.

But it’s not easy to explain why.In this study, the absence or few complications did not directly correlate with blood management. sugar, Says King.

He does not downplay the importance of glycemic control. It has been shown to reduce the risk of complications. However, his research suggests that other mechanisms may help explain the protection from complications he has found in some.

Protection from diabetic complications

King studied 351 so-called medalists who received medals from Joslyn. Diabetes mellitus Center after living together Type 1 diabetes 50 years. In type 1 diabetes, the pancreas does not produce enough Insulin Controls blood sugar levels.To Type 2 diabetes, The body may not produce enough Insulin Or Insulin resistance It occurs when the body does not respond normally to insulin.

Insulin works glucose To the cells it is used for energy.

The average age of the participants was close to 68 years. The age at diagnosis was about 11 years.

King’s team examined common complications, including: Eye problems Retinopathy, neuropathy or neuropathy, kidney disorder or nephropathy, and Cardiovascular disease..

They found it:

  • 43% did not have advanced diabetic eye complications.
  • 87% was free Kidney disease..
  • 39% did not have a neurological disorder.
  • 52% did not have cardiovascular disease.

“Overall, about 20% don’t have eye, kidney, or nerve disease,” King told WebMD.

Role of protein

King’s team evaluated participants’ blood glucose levels. On average, blood sugar levels were well controlled.average Hemoglobin A1c test, The reflection of blood glucose level for the past 3 months was 7.3%. Experts often recommend that diabetics keep A1c below 7%.

However, blood glucose levels did not correlate with a reduced incidence of complications.

To find another explanation, researchers also evaluated a family of proteins known as advanced glycation end products (AGEs).These are increased by Hyperglycemia level.

People with high levels of two specific AGEs were more than seven times more likely to have complications.

Then came the surprise, says King. People with some other combination of measured AGEs were actually protected from eye complications.

According to King, some AGE combinations suggest that they are not believably toxic and may actually be protective.

“Some AGEs can be treated differently from person to person, and those differences can be a source of protection,” he says.

Second opinion

Diabetics with no or few complications “have a fascinating life,” said Aaron Binick, MD, director of research and neuroendocrine units at the Strelitz Diabetes Center at the Eastern Virginia Medical College. Says.

He speculates, among other explanations, that those fleeing complications may have developed good defenses against these ages over the years. These defenses somehow reduce the toxicity of AGEs.

A diabetic veteran who participated in the study said, “He really took care of us.” He says little was known about diabetes treatment when they were diagnosed. At that time, doctors weren’t even talking about strict control of blood sugar levels.

Learning more about diabetics who escape complications may ultimately help researchers intervene in people who are prone to complications, King said.

For now, people with diabetes who want to avoid complications can take pages from a medalist’s book, King says.

“Most people are pretty strict motion At least three times a week for at least 45 minutes, “he says.

Their attitude is positive, King told WebMD. They do not deny their illness and the need to control it.

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Source: Joslin Diabetes Center, Chief Scientific Office, Dr. George L. King, MD. Professor, Harvard Medical School, Doctor of Medicine, Aaron Binick, Director of Research and Neuroendocrine Unit, Norfolk Eastern Virginia School of Medicine, Binick, A. Diabetes treatment, April 2011. vol 34: pp1060-1063.King, G. Diabetes Care, April 2011; Volume 34: pp. 968-974.

© 2011 WebMD, LLC. all rights reserved.

Why Some People Avoid Type 1 Diabetes Complications

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