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The study says the prostate drug finasteride can safely reduce the risk of cancer

Thursday, January 24, 2019 (HealthDay News)-Finasteride, best known as the drug for benign prostatic hyperplasia, reduces the risk of prostate cancer, according to long-term findings on prostate cancer prevention. A safe and effective way to do it. Trial (PCPT).

The study, funded by the National Cancer Institute, enrolled approximately 19,000 men between 1993 and 1997.

Initially, the hormone blocker finasteride was found to reduce the risk of prostate cancer by 25%. These results were published in 2003.

Newly released long-term data show that the risk of prostate cancer continues to decline, with less than 100 men dying from prostate cancer in more than 20 years of follow-up, according to a research team led by Dr. Ian. is showing. Thompson.

The updated results also showed no statistically significant increase in the risk of death from prostate cancer among men taking finasteride. This removes concerns about early detection of potential risk of more aggressive cancer among patients taking the drug.

“Finasteride is a safe, cheap and effective strategy for preventing prostate cancer,” said Thompson, a senior researcher at PCPT on the SWOG Cancer Research Network.

The SWOG Cancer Research Network is an international cancer clinical trial group.

“Physicians should regularly share these results with men who have prostate-specific antigens. [PSA] “We’re testing for the presence of prostate cancer, and the drug will have the greatest effect on men in this group,” Thompson said in a SWOG news release.

Thompson is also an emeritus professor at the University of Texas Health Science Center in Houston.He and his team released their findings on January 23 New England Journal of Medicine..

Cheap and reliable prostate cancer prophylaxis will have a significant impact on public health, Thompson and his colleagues said.

According to the American Cancer Society, they said the incidence of prostate cancer was rising and nearly 165,000 American men were diagnosed with cancer in 2018.

Although many cases of prostate cancer are slow-growing and non-life-threatening, they are often treated with surgery or radiation and can cause complications such as impotence and incontinence.

“There are significant negative impacts on the health and quality of life of patients that can result from the treatment of prostate cancer, as well as their finances and security,” Thompson said.

“If we can save people from surgery and numerous tests and tests and avoid living for years in fear, we should do so. The best scenario for patients is prevention, and this trial puts us there. I found a cheap drug that would lead to surgery, “he concludes.

A prostate expert unrelated to the study said the new findings came after a “long-standing debate” about the role of finasteride in cancer prevention.

Based on early PCPT findings, the U.S. Food and Drug Administration said, “Chronic use of this drug may increase the risk of high-grade or aggressive prostate cancer in a small proportion of men. We have issued a warning, “said Dr. Manish Villa. He supports direct urology research at the Arthur Smith Institute of Urology in Northwell Health, Lake Success, NY.

Unfortunately, the warning “virtually negated the benefits of the drug in the eyes of many patients and their doctors,” Villa said.

After these, he said, more complete results should turn it around.

“Physicians and patients need to be aware of these results and at least reconsider using these drugs to prevent prostate cancer,” Vira said.

“This can be especially true for high-risk men, such as African-American men and men with a strong family history of prostate cancer,” he said.

–Robert Preidt

MedicalNews
Copyright © 2019 Health Day. all rights reserved.


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References

Source: Manish A. Vira, MD, Vice Chairman of Urology Research, Arthur Smith Institute for Urology, Northwell Health, Lake Success, NY. SWOG, News Release, January 23, 2019

The study says the prostate drug finasteride can safely reduce the risk of cancer

Source link The study says the prostate drug finasteride can safely reduce the risk of cancer

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