Researchers grow functional liver tissue in mice

Wednesday, July 19, 2017 (HealthDay News)-Researchers liver Tissue to the fully functional liver of mice.

If this approach works for people, it can help reduce long wait lists liver Transplant. According to researchers, it can also benefit people with poor quality liver transplants and liver malfunctions.

Scientists have put three types of hepatocytes (seed) into a biodegradable tissue scaffold. Next, these scaffolds were transplanted into mice with damaged liver. Once inside the mouse, the small structures grew 50-fold and were able to perform normal liver tissue function.

“It’s just a shortage of organs. Our goal is to one day use this technique to increase the number of transplants made to patients, but now it’s very limited,” said senior author Sangeta. Dr. Batia said. She is a professor of health sciences and technology, electrical engineering and computer science at the Massachusetts Institute of Technology.

Over 17,000 Americans are waiting for a liver transplant.Millions are chronic Kidney disease, like that Cirrhosis And hepatitis,However, Liver transplant, The researcher said.

“These patients are not really candidates for transplant, Liver disease, And they live with it for the rest of their lives.With that population you can imagine their augmentation Liver function With a small genetically engineered liver, this is an idea we’re pretty excited about, “Batia said in a MIT news release.

The researchers said the cells in these procedures could come from the liver, which could not be transplanted. They can also come directly from the liver of people who need the transplanted cells. If this method is successful Drug There is no need to suppress the immune system.

But so far, this study has been successful only in mice. Research that looks promising in animals does not always reach people.

This study was published in the journal on July 19th. Scientific translation medicine..

–Robert Preidt

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Source: MIT, News Release, July 19, 2017

Researchers grow functional liver tissue in mice

Source link Researchers grow functional liver tissue in mice

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