Relationship of Zika fever to rare neuropathy enhanced by research

Latest infectious disease news

Dennis Thompson
Health Day Reporter

Wednesday, October 5, 2016 (HealthDay News)-In a new report, an international team of researchers has developed the strongest evidence to date. Zika virus Can cause a rare neuropathy called Guillain-Barré Syndrome..

A neurologist at Johns Hopkins University, working with researchers at six Colombian hospitals, said they had detected it. Zika virus In the body fluids of a group of people suffering from the symptoms of Guillain-Barré Syndrome..

Guillain-Barré Syndrome is a potentially life-threatening muscle-causing disorder Weaknesses According to research background information, when the immune system attacks nerves.

“This is the first solid evidence that the virus is present in patients with Guillain-Barré syndrome,” said Dr. Carlos Pardo, an associate professor of neurology at Johns Hopkins in Baltimore. “With a large population from multiple affected centers Zika When it did occur, it was able to detect and culture the virus that was affecting these patients. “

This study was conducted on October 5th New England Journal of Medicine..

At least 14 patients cited in the study were diagnosed with both Zika With infectious diseases Guillain-Barré Syndrome Using the highest level of testing available for both illnesses, Dr. Jennifer Frontera said Neurologist With the Cleveland Clinic. She is a co-author of an accompanying editorial.

Zika The first mosquito-borne virus known to cause terrible causes Birth defects, Most of them are related to the brain. However, in the average person, the virus generally causes mild symptoms or no symptoms at all.

Because of the possibility of Birth defects, Public health workers have a special emphasis on protection Pregnant Woman from the virus.

However, the number of cases of Guillain-Barré syndrome, which has been the hardest hit in South American countries, is increasing. ZikaEncourages public health authorities to draw a tentative link between the two.

According to the National Institutes of Health, Guillain-Barré syndrome is rare and usually affects 1 in 100,000 people.But when Zika Guillain-Barré also developed in 1 in 4,000 people infected with the virus that struck French Polynesia a few years ago, Pardo said.

In Colombia, in early 2016, just around the time of the country, “the number of Guillain-Barré cases has increased overwhelmingly.” Zika Outbreak, Pald said. “It went from one or two cases a year to 10 to 15 cases a week. It was very impressive.”

People with Gillan Valley Syndrome experience muscle Weaknesses It can range from slight weakness and tingling in the feet to perfection. paralysis According to Frontera, he needs a ventilator.

“The majority of people will improve from the Gillan Valley over time, but that can be very serious,” she said.

To further shed light on this potential connection, Paldo and his colleagues evaluated 68 patients with Guillain-Barré syndrome in a Colombian hospital. They tested 42 patients and Zika virus..

The researchers determined that 17 patients were tested positive for Zika fever in their urine, using the most advanced genetic tests available for the virus.

Another 18 patients also showed potential evidence of deer infection, the researchers said.But Frontera says this evidence is dengue or yellow fever Infectious diseases since these virus I’m from the same family as Jika.

The research team confirmed Guillain-Barré syndrome in 14 of the genetically validated patients with Zika infection. Researchers used important nerve conduction tests to accurately diagnose neuropathy, Frontera said.

Guillain-Barré Syndrome is another virus Bacterial infectious disease, Including Campylobacter, influenza, yellow fever When Epstein-Barr virusSaid Frontera.

Researchers said that nearly half of the study participants complained of neurological symptoms within four days of the onset of Zika fever.This is an unusually fast response compared to others who develop Gillan Valley Syndrome after being infected by another person. virus, The author of the study said.

Zika and these other infectious agents may create a condition called “molecular mimicry” that causes the immune system to attack the nervous system, Pald and Frontera said.


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According to Frontera, Zika protein may share some similarities with nerve cells in the body and a fat white substance called myelin that lines the nerve cells.

Therefore, she said, the antibodies created to attack Zika could be confusing and attack the nervous system.

Frontera added that Zika may somehow directly attack nerve cells.

Doctors usually treat Guillain-Barré syndrome by exchanging the patient’s plasma or injecting the antibody immunoglobulin into the bloodstream. Both tactics are aimed at short-circuiting the response of the defective immune system, Pardo and Frontera said.

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Source: Carlos Pardo, MD, Associate Professor, Neurology, Johns Hopkins University School of Medicine, Baltimore. Jennifer Frontera, MD, Neurologist, Cleveland Clinic, Cleveland; October 5, 2016, New England Journal of Medicine

Relationship of Zika fever to rare neuropathy enhanced by research

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