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Studies show that gene mutations may send High blood pressure To the next generation
Along Kathleen Doheny
WebMD Health News
Was reviewed by Laura J. Martin, MD
March 31, 2011-Mothers with certain genetic mutations may go through a tendency to develop High blood pressure According to a new study, to their children.
Researchers in the United States, China, and Austria discovered after focusing on five generations of Chinese families.Many of its members are descendants of the same female ancestors High blood pressure..
Researchers have discovered genetic mutations that affect mitochondria in these people. These are the “driving forces” of cells that convert energy into usable forms.This discovery is due to a mutation in mitochondrial DNA High blood pressure For some people.
“This mutation can reduce the energy production of cells,” says Dr. Minsing Ann, a professor of genetics at Zhejiang University in China. It increases the production of free radicals, substances that can damage cells, his team found.
“These mitochondrial dysfunctions High blood pressure“Guan writes.
More than 60 million people in the United States High blood pressure, According to Americans heart Association. More than two-thirds need medication for this condition.Unprocessed amount blood pressure Increase both risks stroke And heart attack..
New research is published in Circular research, Journal of the American Heart Association.
Maternal infection of hypertension
Guan and his team evaluated 106 people from a large family in China. The study began after one of the members developed high blood pressure at the age of 45.
Researchers examined her and found no anomalies to explain the high pressure. They went on to interview other family members. They found that 15 of the 27 mothers’ relatives had high blood pressure after treatment. Only 7 out of 81 non-mother relatives did so.
None of the offspring of the affected father had high blood pressure.
Researchers suspected the involvement of mitochondrial DNA because hypertension was transmitted to the mother. When a child is born, half of the chromosomal DNA is obtained from one parent and half from the other parent. However, mitochondrial DNA is completely inherited from the mother to the child.
There, the researchers analyzed the mitochondrial genome of their maternal relatives. They found that a mutation in the mitochondrial tRNA-Ile gene was involved in reducing cell energy production.
Thomas Giles, MD, a professor of medicine at Turene University School of Medicine in New Orleans and a former president of the American Society, said the findings may not immediately help patients, but may ultimately help a therapeutic approach. It states that it has sex. High blood pressure.. He reviewed the findings of WebMD.
For example, one day, people whose high blood pressure is associated with oxidation stress He says it may be treated with antioxidants.
The increase in free radicals seen in this mutation leads to a decrease in nitric oxide, which helps keep blood vessels relaxed, Giles says. When they contract and narrow, high blood pressure can occur.
If studies support it, Giles says that this type of hypertension associated with mitochondrial dysfunction probably explains a very small percentage of all cases.
Ultimately, scientists may find a way to repair this genetic defect, he says.
1 Weaknesses A feature of the study is that the exact mechanism of how mutations lead to hypertension is certainly unknown, says Donna Arnett, MD, professor and epidemiology director of the Department of Public Health, Birmingham, University of Alabama. Says. She is a spokeswoman for the American Heart Association.
However, she says, the study could lead to genetic screening tests in the future.
Blood pressure is considered high if systolic blood pressure is 140 or higher and diastolic blood pressure is 90 or higher. Systole is the upper limit of blood pressure measurements. It reflects the pressure when the heart contracts. The low diastole reflects the pressure when the heart relaxes.
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Source: Min-Xin Guan, PhD, Researcher, Institute of Genetics, Zhejiang University, Hangzhou, Zhejiang, China.Wang, S. Circulation Research, March 31, 2011. Donna Arnett, MD, Professor and Chair, Epidemiology, School of Public Health, University of Alabama at Birmingham; American Heart Association Spokeswoman. Dr. Thomas Giles, Professor of Medicine, University of Train, New Orleans. Former President of the American Society of Hypertension.
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Moms may pass the risk of high blood pressure to their children
Source link Moms may pass the risk of high blood pressure to their children