Thursday, June 8, 2017 (HealthDay News)-Scary pit vipers may need image upgrades: their poison may end help Human heart Patients, studies suggest.
Taiwanese scientists may prove that a poison-based anticoagulant from the pit viper of Wagler is effective in mice and one day is safer than today’s human anticoagulants. Is called.
One cardiologist pointed out that the relationship between snakes and drugs is not new. This is because poisons are usually killed by destroying the blood coagulation mechanism.
Dr. Satjit Byysri, a cardiologist at Lenox Hill Hospital in New York City, said: In fact, “many of today’s anticoagulants are based on initial experiments with proteins found in snake venom,” he added.
In the new study, a team led by Tur-Fu Huang, a pharmacological researcher at National Taiwan University, Tropidolaemus waglerix Snake-A Southeast Asian species known as the wagler pit viper or temple viper.
The snake venom contains a protein called Troisgrelix, the researchers explained. Huang’s group designed the molecule based on trowaglerix and was able to block GPVI, a protein that is present on the surface of platelet cells and is important for these cells to aggregate to form blood clots. ..
When mixed with blood, the new compound prevented the coagulation of blood cells called platelets.Also, the mice that received the drug were late Blood clot Although formed more than untreated mice, treated mice did not bleed longer than untreated mice. Still, animal experiments often do not lead to human success, so further research is needed.
Dr. Kevin Marzo is the Dean of the Department of Cardiology at NYU Winthrop Hospital in Mineola, NY. After reviewing the findings, we agreed that the drug under development might be beneficial.
“Most of the lifesaving Drug Used to treat heart attack Patients work by suppressing platelets and preventing blood clotting. But it often comes at the expense of serious bleeding complications, “he said.
“The potential development of new drugs based on snake venom, which have similar beneficial effects in preventing blood clotting and may reduce the side effects of bleeding, is an exciting finding that guarantees future research,” Marzo said. Added.
This study was published in the journal on June 8th. Arteriosclerosis, Thrombosis and vascular biology..
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Source: Satjit Bhusri, M..D, Cardiologist, Lenox Hill Hospital, New York City; Dr. Kevin Marzo, MD, Dean of Cardiology at NYU Winthrop Hospital in Mineola, NY. Arteriosclerosis, thrombosis and vascular biology, News Release, June 8, 2016
It’s a snake to rescue heart disease patients
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