Influenza vaccination may help restore heart bypass

Tuesday, November 12, 2019 (American Heart Association News)-Vaccination against influenza before heart bypass surgery may prevent inflammation throughout the body and lead to a healthier recovery, new Studies suggest.

Cardiac surgery is associated with inflammation and altered immune function, said Dr. Faddy Ebrahim, lead author of a preliminary study to be published in Philadelphia on Sunday at the American Heart Association science session.

“This is associated with significant physical stress during invasive procedures,” said Ebrahim, an anesthesiology fellow at the University of Toronto, Ontario.

The study enrolled 30 heart bypass patients at a hospital in Sudbury, Ontario. Fifteen patients were vaccinated against influenza before surgery. The rest were given a placebo. The researchers then tested blood levels of various inflammation-related substances at seven intervals, from the start of the surgery to the end 48 hours after the surgery.

Those who were vaccinated against the flu had lower levels of two chemicals that promote inflammation than those who were vaccinated against placebo. On the other hand, the levels of chemicals that fight inflammation were higher among the vaccinated groups. The difference lasted up to about 24 hours after surgery.

Patients in this study underwent coronary artery bypass graft surgery, the most common heart surgery currently performed worldwide. More than 370,000 people receive this treatment each year in the United States.

Surgery can relieve chest pain known as angina and reduce the risk of a heart attack. In this procedure, arteries or veins are taken from elsewhere in the body and used to reroute blood around the clogged blood vessels that feed the heart. Patients may undergo one or more bypass transplants, depending on the number of coronary arteries that are occluded.

According to Ebrahim, doctors have yet to find a reliable preventative treatment to reduce the rate and severity of the body’s inflammatory response to surgery. Elevated inflammatory response makes patients more susceptible to complications.

Although the new study targeted only a small number of patients, the effect of the flu vaccine on markers of inflammation was significant, said Dr. Jennifer Robinson, director of the Center for Preventive Intervention at the University of Iowa Public Health University. ..

“Vaccines work by activating machines that fight infections in the body,” Robinson said. In a new study, “influenza vaccines had significant protective physiologic effects that could have important implications for reducing postoperative complications.”

However, she said more research is needed to reproduce the findings and see if influenza vaccination can reduce recovery time after surgery.

“Although uncommon, reducing the risk of a postoperative heart attack or stroke will have important implications,” Robinson said.

The study showed that influenza vaccination could affect the inflammatory response immediately after surgery, but the study design did not allow researchers to assess how patients progressed medically. did. Ebrahim said the new findings are the starting point for larger multicenter trials.

American Heart Association news covers heart and brain health. Not all views expressed in this story reflect the official position of the American Heart Association. Copyrighted by American Heart Association, Inc. Owned or owned by, and all rights are reserved.If you have any questions or comments about this story, please email us [email protected]

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Influenza vaccination may help restore heart bypass

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