Genetic research gives new insights into adolescent girls

Amy Norton
Health Day Reporter

Wednesday, July 23, 2014 (HealthDay News)-Girl’s First Timing Menstrual period According to new research, it can be determined by hundreds, or even thousands, of genetic mutations.

Researchers have identified more than 100 DNA regions associated with the timing of menarche. This is the first time for a woman. Menstrual period.. Researchers have found that these discoveries Type 2 diabetes NS breast cancer..

“How are these findings? puberty Timing is related to the risk of illness in later years. ” John Perry, Principal Investigator, MRC Epidemiology Unit, University of Cambridge, UK, said.

“With the help of future research, I hope this leads to a better understanding of the underlying biology behind the following diseases: Type 2 diabetes When breast cancer“Perry said.

Just a while ago puberty Linked to an increased risk of some of today’s most common health problems, including obesity, Type 2 Diabetes, Heart disease When breast cancer..Nevertheless estrogen Levels are believed to be related, and the complete reason for the relationship between menarche and later health status is not clear.

In a new study, some of the genetic regions associated with menarche include hormone production, weight, birth weight, adult height, and Bone density —— Above all.

Perry and his colleagues report their findings in the online version on July 23. Nature..

Examining data on more than 180,000 women, researchers found that girls began to menstruate at very different ages. Some start as early as eight, while others start in high school. exercise level, nutrition And weight are all affected, but Perry pointed out that perhaps many other factors are also involved.

“We have identified more than 100 regions of the genome that are associated with pubertal timing,” he said. “But our analysis suggests that thousands of gene variants, and perhaps genes, are likely to be involved.”

According to Perry, what that means is that “adolescent timing is a much more complex process than we initially thought.”

Dr. Patricia Vguin, a pediatric endocrinologist at the Cohen Children’s Medical Center in New Hyde Park, New York, agreed. “Many of these (genes) are completely new and have never been associated with adolescence,” said Vuguin, who was not involved in the study.

Now she said she has a lot of interest in factors that influence the timing of puberty-partly, children these days have puberty at an earlier age than they did decades ago. Because I’m starting.

Rising tide Childhood obesity Is considered to be an important reason, but research shows that it is not all.

Often Vuguin said parents were thinking about changing something in their child diet -Let’s feed only them Organic food -It will ensure a “healthy” age in adolescence.

“But this (research) says, it’s not that simple,” Vuguin said. “It’s not just body fat and what you eat. It’s much more complicated than that.”

According to Perry, one of the big discoveries was that a “special set” of genes known as imprinted genes could help control pubertal timing. Most genes inherit one copy from each parent, both of which are active. The imprinted genes are different. Only copies from one parent are active and the other is “silent”.

Researchers have believed that imprinted genes are important only prenatally for fetal growth and development.

“Our research supports the idea that these genes continue to play a role in future health and illness,” Perry said.

Both he and Vuguin described the study as the first step in understanding the biology that links adolescent timing to later health.

One of the limitations of my job is that all women were of European descent. However, Perry said he expects genes and underlying biology to be “very similar” to women of all races and ethnicities-and his team is currently studying that question. increase.

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Source: Dr. John RB Perry, Senior Researcher Scientist, MRC Epidemiology Unit, University of Cambridge, UK. Patricia Vuguin, MD, Pediatric Endocrinologist, Steven and Alexandra Cohen Children’s Medical Center, New Hyde Park, NY; July 24, 2014, Nature,online

Genetic research gives new insights into adolescent girls

Source link Genetic research gives new insights into adolescent girls

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