Gene discovery can shed new light on schizophrenia

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Tuesday, July 22, 2014 (HealthDay News)-One of the largest studies ever conducted on the genetic origin of mental illness has discovered 83 new sites on the chromosome. Hereditary Genes associated with schizophrenia..

Findings made by an international team of researchers now bring the total number of common genetic mutations associated with disorders to 108.

These are schizophreniaThe relevant genes are not specific enough to be used as a test to predict who will develop the disease, researchers say, screening high-risk people who may benefit from prophylactic treatment. It says it may be used as a tool someday.

Currently the entire group schizophreniaThe linked gene “explains only about 3.5 percent of the risk schizophreniaDr. Thomas Insel, Director of the National Laboratory of the United States mental health, Said in the agency news release. However, “based on these early predictors, those who score in the top 10% of risk can be up to 20 times more likely to develop the disease. schizophrenia.. “

Previous studies have identified only about 30 common genetic variants associated with. schizophrenia.. All schizophrenia gene samples available to people with schizophrenia by an international team of more than 500 scientists from more than 80 research institutes in 25 countries in looking for more clues to the molecular basis of the disorder Was re-examined.

The combined data included more than 37,000 people with schizophrenia and 113,000 people without disabilities.

The analysis examined the complete human genome, the “map” of the DNA that makes up humans. From a pool of approximately 9.5 million genetic variants, the authors of the study found 108 sites on various chromosomes that appeared to be associated with schizophrenia.

Newly discovered sites are grouped around the pathways associated with the particular process associated with the failure. These include communication between brain cells and pathways that include learning, memory, and immune function. The study found that some sites even focused on specific targets for the treatment of schizophrenia.

One association was identified by mutations in the gene encoding the receptor. Dopamine -A known target of brain chemistry messengers Drug It is used to treat schizophrenia.

Researchers believe that more genetic clues to schizophrenia may be revealed in studies of more patients.

“These results emphasize that genetic programming affects the brain in small, gradual ways that can increase the risk of developing schizophrenia,” said NIMH’s Head of Genomics Research. Thomas Lehner said in a news release. “They also examine strategies to look at both the common and the rare. [gene] A variation to understand this complex obstacle. “

This study was published online on July 22nd Nature..

-Mary Elizabeth Dallas

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Source: National Center of Neurology and Psychiatry, News Release, July 21, 2014

Gene discovery can shed new light on schizophrenia

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