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Diabetes medications may help women with pre-eclampsia prolong pregnancy

According to Denise Mann HealthDay Reporter

Thursday, September 23, 2021 (HealthDay News)

Metformin, Generally prescribed Diabetes mellitus Medications may help stop preterm birth among developing women pregnancy-Related High blood pressure..

Pre-eclampsia Characterized by sudden spikes in blood pressure, Protein in urine, or other problems pregnancy..Premature birth Pre-eclampsia Occurs between 26 and 32 weeks pregnancy And often leads to early delivery, Baby At risk.Premier has health problems at birth and beyond Baby Born at maturity.

“”Pregnant Mother diagnosed with premature birth Pre-eclampsia Then took Metformin stayed Pregnant One week longer than those who took dummy tablets [placebo]”. Research author Dr. Catherine Kluber, an associate professor of obstetrics and gynecology at the Tigerberg Hospital at Stellenbosch University in South Africa, said.

It may sound like a week isn’t that much, but she said it could make a big difference for the baby.

“For preterm birth, it’s beneficial to have a baby staying in the womb every day,” Cluver said. Studies have shown that babies born to women who take metformin spend 12 days less in the hospital than babies born to mothers who take placebo.

Exactly how Metformin Helps Prolong pregnancy Although not fully understood, researchers have a theory.

“when Pregnant Women develop Pre-eclampsiaThere are certain proteins or biomarkers that affect the lining of her blood vessels and increase in the bloodstream. Metformin may improve vascular function and reduce these biomarkers.

the study It included 180 women who developed pre-eclampsia between the 26th and 31st weeks of gestation.

Half took metformin and half took placebo.While a woman taking metformin is staying Pregnant About a week longer than those who did not, the results were not considered statistically significant.

However, they were “biologically important,” said Dr. Ira Bernstein, a member of the Pre-eclampsia Foundation’s Medical Advisory Board, who reviewed the findings. The Foundation helped fund the research.

Bernstein, Head of Obstetrics, Gynecology and Reproductive Sciences at the University of Vermont Learner Medical College in Burlington, said:

Studies have shown that metformin is safe and there was no difference in serious childbirth complications or death between the two groups of mothers or babies.

However, the new study had some limitations.

It was held at a center in Cape Town, South Africa. obesity Have HIV Chronic High blood pressure.. Further research in a larger group of women is needed to see if the findings apply to other populations, Kluber said.

Researchers have set up a large trial involving 500 women with preterm preeclampsia, she said.

Survey results published online on September 23 BMJ.

Pre-eclampsia continues to be a major cause of preterm birth, as well as deaths of newborns and mothers, Bernstein said.

In the United States, women at risk for pre-eclampsia are closely monitored and often taken daily. aspirin He said to reduce their chances of developing this dangerous pregnancy complication.Women who have it are often treated with blood pressure-Reduce and monitor dosages.

The best way to get ahead of pre-eclampsia is to live a daily life Prenatal care, He emphasized. Your doctor will check your blood pressure during these appointments.

Eclampsia often occurs quietly, Bernstein said. “Some women headache Or with rapid swelling Weight gainHowever, these can also occur in normal pregnancies, “he said.



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Dr. Elan Bournestein is Vice-Chair of Obstetrics and Gynecology at Lenox Hill Hospital in New York City.

He described the finding as “interesting and innovative,” but said further research was needed to conclude the potential role of metformin in the treatment of preterm preeclampsia.

“These findings are used to encourage further research in this area to hypothesize and assess both the clinical potential to treat pre-eclampsia and the plausible mechanism of their observations. Should be, “he said.

For more information

For more information on preeclampsia, Eclampsia Foundation..

Source: Catherine Cluver, MD, Associate Professor, Obstetrics and Gynecology, Stellenbosch University, Tigerberg Hospital, Stellenbosch, South Africa. Ira Bernstein, MD, Professor and Chairman, Obstetrics, Gynecology, Reproductive Sciences, University of Vermont, Lerner Medical College, Burlington; Eran Bornstein, MD, Director, Obstetrics, Lenox Hill Hospital, New York City; BMJ, September 22, 2021, online

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Diabetes medications may help women with pre-eclampsia prolong pregnancy

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