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Can obesity delay the response to the COVID vaccine?

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Friday, May 6, 2022 (HealthDay News)

Obesity May complicate the course COVID-19. Now, new research says it could also reduce the effectiveness of COVID Vaccines.

The researchers also found that two Vaccines The different levels of immune responses used in their study triggered severe Obesity People. They also found that a previous infection had affected them.

“These results provide new information about the antibody response SARS-CoV-2 vaccines In heavy people Obesity And reinforce the importance of prioritizing and increasing Vaccine “To be in this vulnerable group,” said Volkan Demirhan Yumuk, co-author of the study, in a press release from the European Congress on Obesity. Yumuk is a professor at Istanbul University, Turkey.

The study included 124 Severely obese adults (Average age 42 to 63 years) and 166 normal weight adults (average age 39 to 47 years) in Turkey. The Obesity The group had a body mass index (BMI) – Size based on height and weight – more than 40.

Participants received two doses of Pfizer / BioNTech Vaccine Or the CoronaVac vaccine made by the Chinese company Sinovac.

Four weeks after receiving the second dose, blood samples were taken from the participants to measure their antibody levels against the corovirus. In addition, their infection history was checked and it was found that 70 were previously infected COVID-19.

The study showed that among participants who had no previous infection and received the Pfizer / BioNTech vaccine, antibody levels among those who were severely overweight were three times lower than in those who were normal weight.

Among those who had no previous infection and received the CoronaVac vaccine, antibody levels were 27 times lower in severely overweight individuals than in those of normal weight.

Among those who had previously been infected and were taking Pfizer / BioNTech or CoronaVac, antibody levels were similar in both obese and normal-weight people, according to the study. The findings are due to be presented at this week’s European Congress on Obesity in Maastricht, the Netherlands.

Findings affect the United States where More than four out of 10 people are obeseAccording to the US Centers for Disease Control and Prevention. More than 9% are severely obese.

“Our study confirms that immune memory induced by a previous infection alters people’s response to vaccination, and suggests that two doses of Pfizer / BioNTech vaccine may produce far more antibodies than those of severely obese people with CoronaVac, regardless of the history of infection,” Yumuk said. Said.

However, Yumuk added, “Further research is needed to determine whether this higher level of antibodies provides more protection. COVID-19. “

The data and conclusions presented at the meetings should be considered in advance before being published in the peer-reviewed medical journal.

More information

For more COVID-19 VaccinesSee US Centers for Disease Control and Prevention.

Source: European Congress on Obesity, News Edition, 5 May 2022

By Robert Preidt HealthDay Reporter

MedicalNews
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Can obesity delay the response to the COVID vaccine?

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