Friday, July 20, 2018 (HealthDay News)-Modified version of botulinum toxin- Botox -Long-term administration to mice pain May be a safer alternative to opioids as a remedy and treatment for sometime Chronic painAccording to British researchers.
They “degraded” the botulinum molecule and reconstructed it with an opioid called dermorphin.The resulting compound (called Derm-BOT) was silenced pain Signals from neurons in the spinal cord of mice.
However, it is not yet known if the compound will have the same effect on people. The results of animal studies are often not the same in humans.
“Derm-BOT injected into the spine relaxes Chronic pain -Those caused by nerve damage, etc.-and avoid the adverse events of tolerance, Addiction Often associated with recurring opioids Drug use“. The co-author of the study, Steve Hunt, is a professor of cell and developmental biology at the University College London.
“It does not affect muscles like botulinum toxin used to reduce Wrinkle But it blocks Neuralgia Up to 4 months without normal impact pain reaction.It can really revolutionize the way Chronic pain If it could be converted into a clinic, it would be treated and the need for daily opioid intake would be eliminated, “Hunt said in a college news release.
This study was published in the journal on July 18th. Scientific translation medicine..
The United States is on the verge of an opioid overdose epidemic. Over 2 million people are opioid addicts, most of whom started with prescribed opioid analgesics. Overdose of opioids is currently the leading cause of death.
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Source: University College London, News Release, July 18, 2018
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