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Artificial pancreas works well in home tests

Serena Gordon
Health Day Reporter

Thursday, September 17, 2015 (HealthDay News)-The latest trial of the artificial pancreas system is Type 1 diabetes -System went down Blood sugar Level without increasing dangerous risk Hypoglycemia (((Hypoglycemia), A new British study says.

Tests conducted by both adults and children at home are based on the system Insulin pump In management Diabetes mellitus, The researchers found.

“This large outpatient real-world study shows that this potentially transformative treatment works for everyone. It can be used in the real world, and it is safe. Most important. The thing is that it’s safe, “said Aaron Kowalski, vice president of the company. JDRF (old boy) research Diabetes mellitus Research Foundation). Kowalski was not directly involved in the study. However, JDRF is funding this system and other artificial pancreas systems under development.

The artificial pancreas is a combination of existing ones Diabetes mellitus Technology- Insulin Continuous with pump glucose Monitor-Uses advanced computer algorithms that tell these devices what to do when blood comes out sugar The level is rising or falling.

Some artificial pancreas systems Insulin, And others can administer both insulin and another hormone called glucagon. The artificial pancreas system used in the current study delivers insulin only.

The system calculates and manages insulin doses according to the blood glucose levels detected by the continuous blood glucose monitor sensor, according to the background information of the study.

However, it is not fully automated (although some other systems under development are automated).Who has Type 1 diabetes Still, you need to calculate the number of carbohydrates in the food they are eating. And, according to the lead author of the study, Dr. Roman Hovolka, director of research at the Institute of Metabolism, University of Cambridge, UK, they must enter that information into a software program.

An effective artificial pancreas Type 1 diabetesAn autoimmune disease in which the body’s immune system accidentally attacks and destroys insulin-producing beta cells in the pancreas.

Insulin is a hormone that helps signal the arrival sugar (Glucose) Used as fuel from food to cells in the body and brain. Type 1 people need to exchange insulin via injection or a small catheter attached to Insulin pump.. However, knowing exactly how much insulin you give is not an easy task. Too much or too little insulin can have dangerous and even fatal consequences.

Ultimately, the artificial pancreas is the food and the human pancreas stress..

“These systems are always one step ahead of the user. Diabetes mellitus.. You will receive fewer alerts and fewer notifications from your device that you are not doing well because the system is doing it for you, “Kowalski said.

Current study includes 58 people Type 1 diabetes.. Thirty-three adults used the system day and night, and 25 children used the system only at night.

According to the survey, all participants used the device at home for 12 weeks.And in another 12 weeks, they managed using the same continuous blood glucose monitor and insulin pump. Diabetes mellitusHowever, there is no artificial pancreas program to guide administrative decisions. According to Kowalski, this is considered a “control” therapy, and such therapy is currently considered “best-in-class care”.

“When used for three months, Hovorka showed the substantial benefits of an artificial pancreas and its integration into people’s normal daily lives. Type 1 diabetes And its family. ”

He added, “Improved glucose control, decreased mean glucose, increased time when glucose was within the target range, and Hypoglycemia Compared to the best sensor-enhanced insulin pump therapy currently available. ”

The results of the study were scheduled to be presented at the European Research Association on Thursday. Diabetes mellitus (EASD) September 17th at the Annual Meeting in Stockholm New England Journal of Medicine To match the presentation.

According to Hovorka, his research group is currently planning to test the artificial pancreas system in longer trials. Up to 1 year in the UK and US. They are also planning a trial in people who are newly diagnosed with type 1 diabetes.



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He said he is working to integrate the devices to minimize the size and weight of the final product.

“this [study] It’s a stepping stone to make the system widely available, “says Hovorka.

Hovorka’s artificial pancreas system is just one of the numbers being developed. Some are developed by academic researchers like Hovorka, while others are designed by diabetes treatment companies.

In 2013, the first artificial pancreas-like system was approved. When blood flows, the insulin supply is cut off. sugar The level drops too quickly. Kowalski said a more automated artificial pancreas system could hit the market in the United States within the next few years.

There is no clear information about the cost of such a system, but Kowalski said it is likely to be similar to the cost of today’s continuous blood glucose monitor sensor augmentation pumps. “Given similar prices and better results,” Kowalski said he was cautiously optimistic that the artificial pancreas system would be at least partially covered by health insurance companies.

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References

Source: Dr. Roman Hovolka, MD, Head of Research, Institute of Metabolism, University of Cambridge, UK. Aaron Kowalski, Ph.D. , Chief Mission Officer, and Vice President of JDRF Research. September 17, 2015, New England Journal of Medicine

Artificial pancreas works well in home tests

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