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Antibiotics for preterm birth associated with cerebral palsy

Amanda Gardner
Health Day Reporter

Thursday, September 18 (HealthDay News)-Antibiotics aren’t just useless Pregnant Women experiencing premature Labor If the membranes rupture and there are no signs of infection, they may increase the risk Cerebral palsy For some children.

Two new studies tracked children whose mother last took antibiotics pregnancy.. Children were tracked up to 7 years old.

“This is a good study because it is a large number of patients and shows that the use of antibiotics is useless and can be harmful to preterm birth. Labor In the absence of membrane rupture (broken water), “said Dr. Jennifer Wu, an obstetrician and gynecologist at Lenox Hill Hospital in New York City.

“There are other medications, but they aren’t really very effective at prolonging pregnancy for more than 48 hours,” Wu added. “There is still no good solution for preterm birth.”

This does not mean that all pregnant women should avoid antibiotics.

Dr. Alan Freishman, Medical Director of the March of Dimes, said:

Preterm children are generally at higher risk Cerebral palsy, Various developmental difficulties and even death during the first month of life. Preterm birth with a ruptured membrane is associated with infection and inflammation.

“It’s important to do this kind of research to reduce premature babies,” Freishmann said. “The use of antibiotics with the first signs of preterm birth has been proposed Labor In fact, you can stop preterm birth LaborWe believe that one of the causes of preterm birth is an unclear low level of infection. ”

New study published online on September 18th LancetWas a follow-up to the original exams called ORACLE I and II. These first trials were conducted to see if antibiotics helped women with potential infections that threatened preterm birth. erythromycin And co-amoxiclav, delay or prevention of preterm birth. The first results did not reveal an increased risk to children.

A new study enrolls children born to 3,298 women in the United Kingdom.

Researchers found that 4.4 percent of children whose mothers took both took both erythromycin And co-amoxiclav Cerebral palsyCompared to 1.6 percent of children whose mothers took only placebo.

At this point, it’s not clear if the risk applies to other antibiotics, the researchers said.

About two out of 1,000 children born at maturity develop cerebral palsy.Those risks are higher Baby I was born early. Overall, the risk for children in this study was 2 in 100, while the risk for children whose mother took one or both antibiotics was 3-4 in 100 children.

Source: Dr. Jennifer Wu, Obstetrician and Gynecologist, Lenox Hill Hospital, New York City. Dr. Alan Freishmann, MD, Medical Director of March of Dimes, White Plains, NY. September 18, 2008, Lancet,online

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Antibiotics for preterm birth associated with cerebral palsy

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