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Antibiotic-resistant typhoid fever spread in Asia and Africa

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Dennis Thompson
Health Day Reporter

Monday, May 11, 2015 (HealthDay News)-The causative agent of antibiotic-resistant bacteria typhoid New studies warn that it has spread to many countries and has reached epidemic levels in Africa.

Strain H58 emerged in South Asia 25 to 30 years ago and grew slowly to become one of the major forms of bacteria. Typhoid feverSaid Vanessa Wong, a research author who is a microbiologist at the University of Cambridge, England.

“This multidrug-resistant strain, H58, is resistant to many first-line antibiotics used to treat disease and continues to evolve and acquire new mutations. DrugWong said.

Typhoid fever does not pose a direct threat to people living in the United States where clean water supply and good sanitation prevent exposure to bacteria, says Henry Chamber, director of infectious diseases at San Francisco General Hospital and professor at the University of California. Dr. Su said. San Francisco.

But Traveler Chambers added that when heading to areas suffering from typhoid fever in Africa and Asia, it is necessary to make sure that they are vaccinated before heading there.

Dr. Wanda Filer, President-elect of the American Academy of Family Physiology, agreed.

“Recommended for anyone traveling somewhere in the world [typhoid] Endemic gets typhoid fever vaccine“The vaccine is 50% to 80% effective for everyone,” Filer said. stock Even those that have become antibiotic resistant are of typhoid fever.

typhoid heat Researchers say that 20 to 30 million people are affected each year worldwide.

Symptoms include high persistence heat, Weaknesses,stomach ache, headache And Decreased appetite.. According to the US Centers for Disease Control and Prevention, 20% of patients can die from complications associated with typhoid infection, which can last for weeks or months without proper treatment. Prevention..

Eating food and drink causes typhoid fever Beverage According to the CDC, it is contaminated with bacteria.Infected person S. Typhoid You can pass it by handling food or drink.. Alternatively, the water used to drink or wash food can be contaminated with sewage containing bacteria.

In this study, a multinational team of researchers used gene sequencing to track the spread of antibiotic-resistant typhoid fever.

The research team discovered that the H58 strain has replaced other strains. typhoid stock It has endured for decades, or even centuries. H58 was identified in nearly half of the more than 1,800 bacterial samples collected from 63 countries between 1992 and 2013.

After the H58 strain emerged in South Asia more than 20 years ago, it spread to Southeast Asia, West Asia, East and South Africa, and Fiji, researchers report.

They also found evidence of an unreported wave of H58 infection in several African countries. This may represent an ongoing epidemic.

The tactics used to fight typhoid fever in these countries appear to have led to an increase Antibiotic resistance, Wong said.

“”vaccination “Currently, it is not widely used in typhoid-endemic countries,” he said. “Instead, antibiotics are commonly used as a preventative measure. As a result, Antibiotic resistance The resurgence of multidrug-resistant typhoid fever against many pathogens has been observed in several regions, including parts of Africa. “

Their findings were published online in the journal on May 11. Nature genetics..

He said Americans traveling to countries with typhoid fever need to be vaccinated and have their temperature monitored in the weeks following their return.If they develop heat, They should talk to their doctor about their trip.

“It’s important to tell your doctor that you’ve been to one of these areas, as certain antibiotics you normally use are ineffective,” he said. “There are already guidelines for using more drug-resistant antibiotics. stock.. “

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References

Source: Vanessa Wong, Ph.D. , Microbiologist, University of Cambridge, United Kingdom; Dr. Henry Chambers of Medicine, Chief of Infectious Diseases at San Francisco General Hospital, Professor at the University of California, San Francisco. Wonder Filer, MD, MBA, President-elect of the American Academy of Family Physics. May 11, 2015, Nature genetics,online



Antibiotic-resistant typhoid fever spread in Asia and Africa

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